CH5424802
- 型號： HY-13011
- 更新時間： 2024-06-03
- 上一個：HY-12071ALDN193189 （Hydrochloride）
- 下一個：HY-13020GSK1838705A
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HY-13011 CH5424802（別名CH5424802）機制：ALK
價格和可用性 技術參數(shù)：
M.Wt：482.62
分子式：C30H34N4O2
純度：> 98％
貯存：貯存在-20℃2年
CAS號：1256580-46-7
溶解性：DMSO≥13mg/mL水分<1.2mg/mL乙醇1.2mg/mL
生物活性：
是一種強效，選擇性，可口服ALK抑制劑。它具有*的化學腳手架，優(yōu)惠的抗腫瘤活性，對癌癥的ALK基因的改變，如非小細胞肺癌（NSCLC）細胞表達EML4-ALK融合和間變性大細胞淋巴瘤（ALCL）細胞表達NPM-ALK融合在體內(nèi)和體外。 ALK L1196M，對應網(wǎng)守突變賦予共同抵抗激酶抑制劑，抑制和阻斷EML4-ALK L1196M驅(qū)動的細胞生長。
HY-13011 (Synonyms CH 5424802) Mechanisms:ALK
Technical Data: Price and Availability of
M.Wt: 482.62
Formula: C30H34N4O2
Purity: >98%
Storage: at -20℃ 2 years
CAS No.: 1256580-46-7
Solubility: DMSO ≥13mg/mL Water <1.2mg/mL Ethanol <1.2mg/mL
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Biological Activity of :
is a potent, selective, and orally available ALK inhibitor. which with a unique chemical scaffold, showing preferential antitumor activity against cancers with gene alterations of ALK, such as nonsmall cell lung cancer (NSCLC) cells expressing EML4-ALK fusion and anaplastic large-cell lymphoma (ALCL) cells expressing NPM-ALK fusion in vitro and in vivo. inhibited ALK L1196M, which corresponds to the gatekeeper mutation conferring common resistance to kinase inhibitors, and blocked EML4-ALK L1196M-driven cell growth.